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Symbol
Name
ID

Tph2
tryptophan hydroxylase 2
MGI:2651811

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

EEG abnormality

Abnormal nonverbal communicative behavior

Delayed speech and language development

Anxiety

Lack of spontaneous play

Impaired ability to form peer relationships

Autism

Inflexible adherence to routines

Motor stereotypy

Restrictive behavior

Intellectual disability

Seizure

Disease(s) Associated with TPH2

autistic disorder

panic disorder

Mouse Phenotypes		nervous system phenotype	abnormal brain morphology	increased brain size	abnormal paraventricular hypothalamic nucleus morphology	abnormal suprachiasmatic nucleus morphology	abnormal hippocampus morphology	abnormal serotonergic neuron morphology	abnormal autonomic nervous system physiology	abnormal nervous system electrophysiology	increased prepulse inhibition
Availability	Mouse Genotype	nervous system phenotype	abnormal brain morphology	increased brain size	abnormal paraventricular hypothalamic nucleus morphology	abnormal suprachiasmatic nucleus morphology	abnormal hippocampus morphology	abnormal serotonergic neuron morphology	abnormal autonomic nervous system physiology	abnormal nervous system electrophysiology	increased prepulse inhibition
	Tph2^tm1.2Kpl/Tph2^tm1.2Kpl	*
	Tph2^tm1Bdr/Tph2^tm1Bdr
	Tph2^tm1Dmkh/Tph2^tm1Dmkh	*
	Tph2^tm1Mca/Tph2^tm1Mca
	Tph2^em1(IMPC)Mbp/Tph2⁺
	Tph2^tm1Pasq/Tph2^tm1.1Pasq	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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